What Cruise Lines Go Down the Mississippi River for Scenic Journeys

American Cruise Lines and Viking River Cruises are the top operators offering scenic journeys down the Mississippi River, combining luxury, history, and breathtaking views. These lines feature immersive itineraries with stops at iconic ports like New Orleans, Memphis, and Natchez, showcasing the river’s cultural and natural wonders.

Key Takeaways

• American Cruise Lines: Offers intimate, all-inclusive Mississippi River journeys with themed itineraries.
• American Queen Voyages: Features historic paddlewheelers and immersive cultural experiences along the river.
• River cruise duration: Most trips range from 7 to 14 days for scenic exploration.
• Top departure cities: New Orleans, Memphis, and St. Louis are popular starting points.
• Unique excursions: Choose lines offering guided tours of antebellum homes and jazz heritage sites.
• Best time to sail: Spring and fall provide ideal weather and fewer crowds.

Why the Mississippi River Is a Bucket-List Destination for River Cruising

The Mississippi River, a ribbon of history, culture, and natural beauty winding over 2,300 miles from northern Minnesota to the Gulf of Mexico, is more than just a waterway—it’s a living chronicle of America’s soul. From the jazz-filled streets of New Orleans to the antebellum mansions of Natchez and the frontier spirit of St. Louis, the Mississippi offers a unique blend of scenic vistas, rich heritage, and Southern charm. For travelers seeking a slower, more immersive way to experience the heartland of the United States, a river cruise down the Mississippi is an unparalleled journey. Unlike ocean cruises, which focus on destinations, river cruises emphasize the journey itself—the ever-changing landscapes, the quiet moments of reflection, and the intimate encounters with local life along the banks.

In recent years, river cruising on the Mississippi has surged in popularity, with luxury and boutique cruise lines investing in new vessels, curated itineraries, and authentic onboard experiences. Whether you’re drawn by the allure of Mark Twain’s literary legacy, the haunting melodies of Delta blues, or the architectural splendor of the Deep South, there’s a cruise tailored to your interests. But with so many options emerging, one question remains: what cruise lines go down the Mississippi River for scenic journeys? This guide explores the top operators offering unforgettable Mississippi River experiences, highlighting their unique features, itineraries, onboard amenities, and tips for choosing the perfect voyage. From historic paddlewheelers to modern river yachts, discover the cruise lines that are redefining American river travel.

Top Cruise Lines Offering Mississippi River Journeys

Several cruise lines have established themselves as leaders in Mississippi River cruising, each bringing a distinct flavor to the experience. While some focus on luxury and all-inclusive service, others emphasize cultural immersion and historical storytelling. Below are the premier operators currently offering scenic journeys along the Mississippi, with a mix of classic and modern vessels designed for comfort, safety, and maximum enjoyment.

American Cruise Lines: Pioneers of U.S. River Cruising

American Cruise Lines (ACL) is arguably the most experienced and expansive operator on the Mississippi River. With a fleet of modern riverboats and paddlewheelers, ACL offers a range of itineraries from 7 to 22 days, covering the Upper, Middle, and Lower Mississippi. Their vessels, such as the American Harmony, American Jazz, and the newer American Symphony, are designed specifically for U.S. waterways and feature spacious staterooms, open-air lounges, and panoramic viewing areas.

• Key Itineraries: 8-day “Lower Mississippi River Cruise” (Memphis to New Orleans), 15-day “Grand Heartland Cruise” (St. Louis to New Orleans), and 22-day “Complete Mississippi River Cruise” (from St. Paul to New Orleans).
• Onboard Highlights: All-inclusive dining with Southern cuisine, nightly entertainment featuring regional music, and guided shore excursions included in every cruise.
• Unique Feature: ACL’s “River Heritage” program includes onboard historians and curated lectures on Civil War sites, plantation life, and the evolution of American music.

ACL’s emphasis on American culture and history makes it ideal for travelers interested in the nation’s past and present. Their smaller ships (carrying 100–190 passengers) ensure an intimate atmosphere and easy access to smaller ports like Vicksburg, Natchez, and Baton Rouge.

American Queen Voyages: The Grandeur of the Paddlewheeler Era

American Queen Voyages (AQV), now part of Hornblower Group, is synonymous with the golden age of river travel. Their flagship, the American Queen, is the world’s largest authentic paddlewheeler, powered by steam and evoking the romance of 19th-century riverboats. The company also operates the American Countess and American Duchess, modern river yachts with a vintage aesthetic.

• Key Itineraries: 7-day “Great River Journey” (Memphis to New Orleans), 15-day “Heart of the Delta” (New Orleans to Memphis), and 22-day “Complete Mississippi River Experience” (from St. Paul to New Orleans).

< Onboard Highlights: Live jazz and blues performances, a working steam calliope, a grand dining room with white-glove service, and an open-air observation deck.

• Unique Feature: AQV’s “Riverlorian” program features expert narrators who provide real-time commentary during scenic stretches, such as the Natchez Trace or the Great River Road.

For travelers who want to feel like they’ve stepped back in time, AQV delivers a theatrical, nostalgic experience. The American Queen’s daily “calliope concerts” and evening “steamboat races” (where the ship “races” a virtual competitor) are beloved traditions.

UnCruise Adventures: Intimate, Eco-Focused River Journeys

While not a traditional river cruise line, UnCruise Adventures has entered the Mississippi market with a unique, small-group approach. Operating the Safari Voyager (a repurposed coastal vessel adapted for river cruising), UnCruise focuses on sustainability, wildlife, and off-the-beaten-path exploration.

• Key Itineraries: 7-day “Mississippi River: From Blues to Bayou” (Memphis to New Orleans), emphasizing cultural immersion and eco-tourism.
• Onboard Highlights: Small groups (max 36 passengers), kayaking and paddleboarding excursions, and a focus on local cuisine and storytelling.
• Unique Feature: UnCruise partners with local historians, musicians, and chefs to offer authentic experiences, such as private blues club visits and cooking classes with Southern home cooks.

Ideal for adventure-seekers and eco-conscious travelers, UnCruise offers a more active, participatory experience. Their itineraries often include hikes in the Mississippi Delta and visits to lesser-known cultural sites.

Scenic Highlights Along the Mississippi River Route

One of the greatest draws of a Mississippi River cruise is the sheer variety of scenic and cultural experiences along the way. From rolling farmlands and cypress swamps to bustling river towns and historic battlefields, each stretch of the river offers something unique. Here’s a breakdown of the most scenic and historically significant sections of the journey, along with what you can expect to see and do.

The Upper Mississippi: Nature and History in Harmony

The Upper Mississippi, from St. Paul, Minnesota, to St. Louis, Missouri, is characterized by dramatic bluffs, forested islands, and charming river towns. This stretch is ideal for nature lovers and history buffs alike.

• Key Stops: Red Wing, MN (known for its pottery and scenic bluffs); La Crosse, WI (home to the Great River Road); and Hannibal, MO (Mark Twain’s boyhood home).
• Scenic Features: The river here is narrow and winding, with towering limestone bluffs, bald eagle nesting areas, and abundant wildlife. The Upper Mississippi River National Wildlife and Fish Refuge is a highlight for birdwatchers.
• Onboard Experience: Cruise lines like ACL and AQV offer naturalist-led commentary, binoculars, and even spotting scopes for wildlife viewing.

Tip: Book a window or balcony stateroom for the Upper Mississippi—the views of the bluffs and river bends are breathtaking, especially at sunrise.

The Middle Mississippi: Heartland Culture and Civil War Legacy

From St. Louis to Vicksburg, the Middle Mississippi is where the river widens and the pace slows. This region is steeped in Civil War history, with key battle sites and antebellum architecture.

• Key Stops: Cape Girardeau, MO (historic riverfront); Memphis, TN (home of Beale Street and the National Civil Rights Museum); and Vicksburg, MS (site of the pivotal 1863 siege).
• Scenic Features: The river here is flanked by cotton fields, historic plantations, and the bluffs of the Tennessee Valley. The Natchez Trace Parkway runs parallel in parts, offering scenic drives.
• Onboard Experience: Many cruises include guided tours of Vicksburg National Military Park and private performances at Memphis’s historic music venues.

Tip: Don’t miss a visit to the Delta Blues Museum in Clarksdale, MS—some cruises offer exclusive after-hours access or live jam sessions with local musicians.

The Lower Mississippi: Antebellum Grandeur and Bayou Magic

The Lower Mississippi, from Vicksburg to New Orleans, is the most iconic stretch, with grand plantations, Creole culture, and the vibrant energy of the Crescent City.

• Key Stops: Natchez, MS (over 500 antebellum homes); Baton Rouge, LA (Louisiana State Capitol); and New Orleans (jazz, cuisine, and Mardi Gras).
• Scenic Features: The river widens dramatically, with cypress swamps, Spanish moss-draped trees, and the occasional alligator sighting. The Great River Road offers stunning views from the banks.
• Onboard Experience: Expect Creole cooking demonstrations, Cajun dance lessons, and jazz brunches. Some cruises dock overnight in New Orleans for a full day of exploration.

Tip: If possible, book a cruise that ends in New Orleans—spend an extra day or two to explore the French Quarter, Garden District, and local food scene.

Choosing the Right Mississippi River Cruise for You

With so many options, selecting the perfect Mississippi River cruise can feel overwhelming. The key is to match your travel style, interests, and budget with the right cruise line and itinerary. Here are the most important factors to consider when making your decision.

1. Duration and Itinerary Length

Cruises range from 7 days (ideal for a long weekend) to 22 days (for a comprehensive journey). Shorter itineraries often focus on the Lower Mississippi (Memphis to New Orleans), while longer ones cover the entire river.

• Best for: First-time cruisers or those with limited time: 7–8 days. Travelers seeking a deep dive into U.S. history and culture: 15+ days.
• Example: ACL’s 8-day “Lower Mississippi” cruise includes Memphis, Vicksburg, Natchez, and New Orleans—perfect for sampling the region’s highlights.

2. Vessel Type and Passenger Capacity

Smaller ships (under 200 passengers) offer intimacy and access to smaller ports. Larger vessels (like the American Queen) provide more amenities and entertainment options.

• Small Ships (50–150 passengers): American Cruise Lines, UnCruise Adventures. Ideal for quiet, personalized experiences.
• Mid-Size to Large (150–400 passengers): American Queen Voyages. Better for those who enjoy onboard activities and social events.

3. Onboard Experience and Dining

All-inclusive vs. à la carte, regional cuisine vs. international menus—dining is a major differentiator.

• ACL: All-inclusive with Southern comfort food and regional specialties (think gumbo, jambalaya, and fried catfish).
• AQV: Fine dining with a formal atmosphere, including wine pairings and multi-course meals.
• UnCruise: Casual, farm-to-table meals with local ingredients and cooking demonstrations.

Tip: If you have dietary restrictions, check with the cruise line in advance—most can accommodate gluten-free, vegan, or kosher diets.

4. Shore Excursions and Cultural Immersion

Look for cruises that include guided tours, private access, and local interactions.

• Best for Culture: AQV’s “Riverlorian” program and UnCruise’s partnerships with local artists and chefs.
• Best for History: ACL’s onboard historians and Vicksburg battlefield tours.

What to Pack and Practical Tips for a Mississippi River Cruise

Preparing for a river cruise requires a mix of practicality and comfort. The Mississippi region experiences hot, humid summers and mild winters, with frequent rain showers. Here’s what to pack and how to prepare for a smooth, enjoyable journey.

Essential Packing List

• Clothing: Lightweight, breathable fabrics (linen, cotton) for daytime. Pack a light jacket or sweater for cool evenings. Bring a rain jacket or poncho—afternoon thunderstorms are common.
• Footwear: Comfortable walking shoes for shore excursions. Sandals or water shoes for deck lounging. A pair of dressier shoes for formal nights (if offered).
• Accessories: Sunscreen, wide-brimmed hat, and sunglasses. A refillable water bottle (many ships have filtered water stations).
• Electronics: Camera, binoculars for wildlife, and a power bank. Wi-Fi is available on most ships, but speeds can be slow.

Health and Safety Tips

• Sun Protection: The river reflects sunlight, increasing UV exposure. Reapply sunscreen every 2 hours.
• Hydration: Drink plenty of water, especially in summer when temperatures exceed 90°F (32°C).
• Allergies: Pollen and humidity can trigger allergies. Pack antihistamines and a small humidifier if needed.
• Motion Sickness: The river is generally calm, but some people experience mild seasickness. Bring ginger chews or motion sickness bands as a precaution.

Booking and Travel Logistics

• Best Time to Cruise: Spring (March–May) and fall (September–November) offer mild weather and fewer crowds. Summer is hot but vibrant; winter is quiet but can be rainy.
• Booking Early: Popular itineraries (like New Orleans departures) sell out 6–12 months in advance. Early booking often includes perks like free airfare or cabin upgrades.
• Airport Transfers: Most cruise lines offer shuttle services from nearby airports. Confirm pickup times in advance.

Data Table: Comparison of Top Mississippi River Cruise Lines

Feature	American Cruise Lines	American Queen Voyages	UnCruise Adventures
Vessel Type	Modern riverboats & paddlewheelers	Authentic steam paddlewheeler & river yachts	Repurposed coastal vessel (river-adapted)
Passenger Capacity	100–190	200–400	36
Itinerary Length	7–22 days	7–22 days	7 days
Onboard Dining	All-inclusive, Southern cuisine	Fine dining, multi-course meals	Casual, farm-to-table
Shore Excursions	Included, guided tours	Included, with Riverlorian commentary	Included, eco-focused & cultural
Best For	History buffs, first-time cruisers	Romantic, nostalgic travelers	Adventure-seekers, eco-tourists
Price Range (per person, 7-day cruise)	$4,000–$7,000	$6,000–$10,000	$5,000–$6,500

Conclusion: Embark on a Journey Through America’s Heartland

A cruise down the Mississippi River is more than a vacation—it’s a voyage through the soul of America. Whether you’re drawn to the literary echoes of Mark Twain, the soulful rhythms of the Delta blues, or the architectural grandeur of antebellum mansions, the river offers a tapestry of experiences that few destinations can match. From the intimate luxury of American Cruise Lines to the nostalgic charm of American Queen Voyages and the adventurous spirit of UnCruise Adventures, there’s a cruise line and itinerary to suit every traveler’s dream.

When planning your journey, consider what matters most to you: the depth of historical immersion, the quality of onboard dining, the size of the vessel, or the authenticity of cultural interactions. Pack thoughtfully, book early, and prepare to be enchanted by the slow, steady flow of the Mississippi—a river that has shaped a nation and continues to inspire travelers from around the world. So, what cruise lines go down the Mississippi River for scenic journeys? Now you know—and the adventure of a lifetime awaits. All aboard.

Frequently Asked Questions

Which cruise lines offer scenic journeys down the Mississippi River?

Several cruise lines operate scenic journeys along the Mississippi River, including American Cruise Lines, Viking River Cruises, and American Queen Voyages. These companies focus on immersive experiences, highlighting historic ports, cultural landmarks, and riverfront views.

What cruise lines go down the Mississippi River with themed itineraries?

American Queen Voyages and Viking River Cruises provide themed itineraries, such as Civil War history, jazz culture, and Mark Twain-inspired voyages. These curated trips combine onboard lectures, local excursions, and live entertainment for a unique experience.

Are there luxury cruise lines that sail the Mississippi River?

Yes, Viking River Cruises and American Cruise Lines offer luxury-focused Mississippi River journeys with premium amenities like spacious staterooms, fine dining, and curated shore excursions. Their ships are designed to blend modern comfort with classic riverboat elegance.

What is the best time of year to take a Mississippi River cruise?

Spring (April–June) and fall (September–October) are ideal for Mississippi River cruises, offering mild weather and fewer crowds. These seasons also coincide with vibrant foliage and blooming landscapes, enhancing the scenic journey.

Do Mississippi River cruise lines offer family-friendly options?

While most Mississippi River cruises cater to adults, American Cruise Lines and American Queen Voyages occasionally offer family-friendly sailings with kid-friendly excursions and activities. Check specific itineraries for age-appropriate programs.

How long are typical Mississippi River cruises?

Mississippi River cruises range from 7 to 15 days, with most itineraries covering segments between St. Louis, Memphis, and New Orleans. Longer journeys may include round-trip voyages or extended stops at historic river towns.